Manganese is an essential trace element that is a component of a number of enzymes needed for metabolism; the body also uses it to build bone tissue and connective tissue and carry out various other functions. Manganese has an antioxidant affect that protects against tissue damage from burning fats. Most Manganese is concentrated in the bones, liver, pancreas, and brain. Manganese activates enzymes that are necessary to form cartilage and connective tissue in bones and skin as well as working with Vitamin K to promote proper blood clotting and wound healing.