Hesperidin is one of the bioflavinoids, naturally occurring nutrients usually found in association with Vitamin C. Some symptoms originally thought to be due to Vitamin C deficiency such as bruising due to capillary fragility were found in early studies to be relieved by crude vitamin C extract but not by purified Vitamin C. The bioflavinoids, sometimes called Vitamin P, were found to be the essential component in correcting this bruising tendency and improving the permeability and integrity of the capillary lining. These bioflavinoids include Hesperidin, Citrin, Rutin, Flavones, Flavonals, Calechin, and Quercetin.

Hesperidin deficiency has been linked with abnormal capillary leakiness as well as pain in the extremeities causing achi-ness, weakness, and night leg cramps. Supplemental hesperidin may also help reduce edema or excess swelling in the legs due to fluid accumulation. Like other bioflavinoids, hesperidin works best when given with Vitamin C and other bioflavinoids. No signs of toxicity have been observed with normal intake of hesperidin.